C’est à la qualité des publications scientifiques que l’on évalue le travail des chercheurs. Ces publications dans des revues internationales comme Nature, Nature Genetics, the Lancet, PLoS One, PLoS Medicine, Gut, the New England Journal of Medicine… sont le reflet de l’excellence de la production. La bibliométrie, incluant une évaluation quantitative des facteurs d’impact dans les revues prestigieuses, reflète l’intérêt de la communauté scientifique pour les découvertes qui sont ainsi reprises et citées.
La bibliométrie évalue l’activité de la recherche en appliquant des méthodes statistiques aux publications scientifiques (bibliographie des articles, signatures des articles, mots-clés et auteurs…). Elle permet de mesurer la production scientifique et la notoriété d’un chercheur, d’un laboratoire, d’un établissement, d’un pays ou d’un domaine de recherche.
- The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodiesSignificanceThere is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death… Lire la suite »
- Plasma Levels of Free NƐ-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in HumansN-carboxymethyl-lysine (CML) and other dietary advanced glycation end-products (AGEs) are chemically modified amino acids with potential toxicological effects putatively related to their affinity with the receptor for AGEs (RAGE). The goal of this study was to determine the postprandial kinetics of CML in both rodents and humans and, in the… Lire la suite »
- Take-home messages from the COPD 2021 biennial of the French Society of Respiratory Diseases. Understanding to so as to better innovateCONCLUSIONS: The dynamism of COPD research was repeatedly underlined, and needs to be further reinforced, the objective being to "understand so as to better innovate" so as to develop effective new strategies for treatment and management of COPD. Lire la suite »
- Effects of Proton Pump Inhibitors Intake During Chemoradiotherapy for Rectal Cancer: a Retrospective Cohort StudyCONCLUSION: No significant association was observed between PPI co-medication and complete pathological response or survival in patients treated for locally advanced rectal cancer. However, the safety of PPIs could not be confirmed. Further ancillary studies of prospective clinical trials or studies using the Health Data Hub are necessary to explore… Lire la suite »
- Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translationWe assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P Lire la suite »
- Fast Protein Modification in the Nanomolar Concentration Range Using an Oxalyl Amide as Latent ThioesterWe show that latent oxalyl thioester surrogates are a powerful means to modify peptides and proteins in highly dilute conditions in purified aqueous media or in mixtures as complex as cell lysates. Designed to be shelf-stable reagents, they can be activated on demand to enable ligation reactions withpeptide concentrations as… Lire la suite »
- Metal enriched quasi-ultrafine particles from stainless steel gas metal arc welding induced genetic and epigenetic alterations in BEAS-2B cellsRecent evidence has supported welding fume (WF)-derived ultrafine particles (UFP) could be the driving force of their adverse health effects. However, UFP have not yet been extensively studied and are currently not included in present air quality standards/guidelines. Here, attention was focused on the underlying genetic and epigenetic mechanisms by… Lire la suite »
- Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcriptionCaffeine is the most consumed psychoactive substance worldwide. Strikingly, molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal-omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus,… Lire la suite »
- The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signallingThe homologous proteins Gas6 and protein S (ProS1) are both natural ligands for the TAM (Tyro3, Axl, MerTK) receptor tyrosine kinases. ProS1 selectively activates Tyro3; however, the precise molecular interface of the ProS1-Tyro3 contact has not been characterised. We used a set of chimeric proteins in which each of the… Lire la suite »