Publications scientifiques
C’est à la qualité des publications scientifiques que l’on évalue le travail des chercheurs. Ces publications dans des revues internationales comme Nature, Nature Genetics, the Lancet, PLoS One, PLoS Medicine, Gut, the New England Journal of Medicine… sont le reflet de l’excellence de la production. La bibliométrie, incluant une évaluation quantitative des facteurs d’impact dans les revues prestigieuses, reflète l’intérêt de la communauté scientifique pour les découvertes qui sont ainsi reprises et citées.
La bibliométrie évalue l’activité de la recherche en appliquant des méthodes statistiques aux publications scientifiques (bibliographie des articles, signatures des articles, mots-clés et auteurs…). Elle permet de mesurer la production scientifique et la notoriété d’un chercheur, d’un laboratoire, d’un établissement, d’un pays ou d’un domaine de recherche.
- MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical PhenotypesCONCLUSION: Radiomics extracted from T2-FLAIR images of AIS patients capture microstructural damage of the cerebral parenchyma and correlate with clinical phenotypes, suggesting different radiographical textural abnormalities per cardiovascular risk profile. Further research could evaluate radiomics to predict the progression of WMH and for the follow-up of stroke patients' brain health. Lire la suite »
- Recanalized Coronary Thrombus: Role of OCT in Identifying a Slow-Evolving and Underestimated Coronary LesionPathological studies have revealed spontaneous recanalized coronary thrombi as a frequent evolution of coronary occlusions; however, they are poorly recognized on coronary angiography, and the optimal therapeutic strategy for clinical evolution is unknown. We report the role of optical coherence tomography in identifying a recanalized coronary thrombus causing myocardial ischemia… Lire la suite »
- Frequency Drift in MR Spectroscopy at 3TPURPOSE: Heating of gradient coils and passive shim components is a common cause of instability in the B(0) field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time… Lire la suite »
- Adaptive Variation of Buchnera Endosymbiont Density in Aphid Host Acyrthosiphon pisum Controlled by Environmental ConditionsThe scarcity of transcriptional regulatory genes in Buchnera aphidicola, an obligate endosymbiont in aphids, suggests the stability of expressed gene patterns and metabolic pathways. This observation argues in favor of the hypothesis that this endosymbiont bacteria might contribute little to the host adaptation when aphid hosts are facing challenging fluctuating… Lire la suite »
- Pharmacokinetics of enoxaparin in COVID-19 critically ill patientsCONCLUSION: In ICU COVID-19 patients, exposure to enoxaparin is reduced due to an increase in the volume of distribution and clearance. Consequently, enoxaparin 40 mg qd is suboptimal to attain thromboprophylactic anti-Xa levels. Lire la suite »
- Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilliPathogenomic evidence suggests that Mycobacterium tuberculosis (MTB) evolved from an environmental ancestor similar to Mycobacterium canettii, a rare human pathogen. Although the adaptations responsible for this transition are poorly characterized, the ability to persist in humans seems to be important. We set out to identify the adaptations contributing to the… Lire la suite »
- An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cellsHere, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of luciferase enzymatic activity. Second, to comply with EMA and FDA guidelines to mitigate drug-drug… Lire la suite »
- Intragenic Distribution of IS6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic ResistanceAntibiotic resistance is a global challenge for tuberculosis control, and accelerating its diagnosis is critical for therapy decisions and controlling transmission. Genotype-based molecular diagnostics now play an increasing role in accelerating the detection of such antibiotic resistance, but their accuracy depends on the instructed detection of genetic variations. Genetic mobile… Lire la suite »
- Diagnosis and management of heart failure from hospital admission to discharge: A practical expert guidanceHeart failure (HF) has high event rates, mortality, and is challenging to manage in clinical practice. Clinical management is complicated by complex therapeutic strategies in a population with a high prevalence of comorbidity and general frailty. In the last four years, an abundance of research has become available to support… Lire la suite »
Flux RSS WordPress par Theme Mason