Nuclear receptors, metabolic and cardiovascular diseases
Lille University – Lille University Hospital – Inserm – Institut Pasteur de Lille
Director : Bart Staels
UMR1011 teams study, through complementary molecular and cellular biology approaches, and through (patho) physiological approaches and integrated technological expertise, the mechanisms at the origin of alterations in lipid and glucose metabolism, and immune system occurring in pathophysiological conditions such as metabolic syndrome, non-alcoholic steatohepatitis (NASH) and type 2 diabetes as well as its associated cardiovascular complications (atherosclerosis, heart failure, valve disease).

Identify new therapeutics strategies
One of the main areas of research is the role of nuclear receptors as regulators and pharmacological targets of these pathophysiological conditions. The validation by translational approaches of our research is an important objective, which we carry out thanks to a close interaction with the clinicians of the unit, EGID (Labex European Genomic Institute of Diabetes) and (inter) national collaborations. allowing studies on human cohorts and biobanks (ABOS in EGID, 2 RHU programs, Resolve EU FP7, TOMIS / CALMOS, Leducq LEAN etc …).
Our objective is to transpose the experimental results to the patients and, reciprocally, the clinical observations towards experimental approaches to generate new hypotheses to be verified at the molecular / cellular level thanks in particular to specific animal models. Our ultimate goal is to identify new targets, diagnostic and therapeutic strategies to prevent and treat these pathologies.
Our ambition is to maintain our high international visibility and to remain at the forefront in this field.
Research teams
Inter-organ cross-talk in cardiometabolic diseases
Group leader : Bart Staels
Cardiac pathologies, blood flow abnormalities and haemostasis
Group leaders : Sophie Susen / Eric Van Belle
Immuno-metabolic dialogue in obesity and its comorbidities
Group leader : David Dombrowicz
Integrated transcriptional analysis of diseases of the liver
Group leader : Philippe Lefebvre
Nuclears receptors and circadian rythms in pathophysiology
Group leader : Hélène Duez
