Public health and molecular epidemiology of age-related diseases

Team 1 – INSERM U1167 – Lille University – CHU Lille – Institut Pasteur de Lille

Presentation

Highlights

• We evaluated the long-term temporal trends (1986-2013) of the prevalence of cardiovascular risk factors, of estimated risk of coronary heart disease and of mortality in the urban community of Lille using the Lille ischemic heart disease registry and four cross-sectional studies (1986, 1995, 2006, 2011 – age 40-64, n = 4538). In men, the age-standardized prevalence fell from 70% to 42% for hypertension, from 71% to 58% for dyslipidemia and from 44% to 24% for smoking. The prevalence of overweight increased from 60% to 65%. In women, the prevalence decreased from 56% to 34% for hypertension and from 60% to 42% for dyslipidemia. The prevalence of smoking (17%) and overweight (50%) remained stable. At the same time, the observed coronary mortality rate fell by 2.6% in men and by 2.8% in women. This decrease was correlated with the decrease in the average fatal coronary disease risk, estimated over 10 years with a coronary risk equation i.e. a decrease of 2% per year for men and of 1.6% for women. These data indicate that primary prevention has made a significant contribution to reducing coronary heart disease mortality (Clement et al. (2017). Arch Cardiovasc. Dis. 110 :689) https://pubmed.ncbi.nlm.nih.gov/28958407/).

• Our participation in the NCD-RisC consortium through the general population samples MONICA, MONA LISA and ELISABET, resulted in several new publications including one describing the evolution of the trajectories of the height and the body mass index different across countries, among children and adolescents between 1985 and 2019 (Lancet 2020; 396:1511, https://pubmed.ncbi.nlm.nih.gov/33160572/).

• Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. We assessed the relationship between exposure to multiple air pollutants and the incidence of coronary heart disease (CHD) in a general population sample. In the single pollutant analysis, PM10, NO2, cadmium, copper, nickel, and palladium were significantly associated with CHD rates. Multiple air pollution was associated with an increased risk of CHD. Single pollutants reflecting road traffic pollution were the most strongly associated with CHD. Our present results are consistent with the literature data on the impact of road traffic on the CHD risk in urban areas (Oscelli et al. (2020). Sci. Total. Environ. 714 : 136608) ; https://pubmed.ncbi.nlm.nih.gov/32018947/).

Members

Luc DAUCHET
MCU-PH, Univ Lille
ORCID number : 0000-0002-2398-0596

Manon HOSTENS
Resident

Cécile VANWALSCAPPEL
MD IPL

Camille CALAFAT
Technician, IPL

Frédéric LOBEZ
Technician, IPL

Publications

Kotseva K, De Bacquer D, Jennings C, Gyberg V, De Backer G, Rydén L, Amouyel P, Bruthans J, Cifkova R, Deckers JW, De Sutter J, Fraz Z, Graham I, Keber I, Lehto S, Moore D, Pajak A, Wood D.
EUROASPIRE Investigators. Adverse lifestyle trends counter improvements in cardiovascular risk factor management in coronary patients.
J Am Coll Cardiol. 2015; 66(14):1634-1636.

Debette S, Kamatani Y, Metso TM, Kloss M, Chauhan G, Engelter ST, Pezzini A, Thijs V, Markus HS, Dichgans M, Wolf C, Dittrich R, Touzé E, Southerland AM, Samson Y, Abboud S, Béjot Y, Caso V, Bersano A, Gschwendtner A, Sessa M, Cole J, Lamy C, Medeiros E, Beretta S, Bonati LH, Grau AJ, Michel P, Majersik JJ, Sharma P, Kalashnikova L, Nazarova M, Dobrynina L, Bartels E, Guillon B, van den Herik EG, Fernandez-Cadenas I, Jood K, Nalls MA, De Leeuw FE, Jern C, Cheng YC, Werner I, Metso AJ, Lichy C, Lyrer PA, Brandt T, Boncoraglio GB, Wichmann HE, Gieger C, Johnson AD, Böttcher T, Castellano M, Arveiler D, Ikram MA, Breteler MM, Padovani A, Meschia JF, Kuhlenbäumer G, Rolfs A, Worrall BB; International Stroke Genetics Consortium, Ringelstein EB, Zelenika D, Tatlisumak T, Lathrop M, Leys D, ; the CADISP group, Amouyel P, Dallongeville J. 
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.
Nat Genet. 2015; 47(1):78-83.

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, …(215)…, Kathiresan S.
Exome-wide association study of plasma lipids in >300,000 individuals.
Nat Genet. 2017; 49(12):1758-1766.

Malik R, …(14)…, Amouyel P, …(407)…, Dichgans M; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Nat Genet. 2018; 50(4):524-537.

Meirhaeghe A, Montaye M, Biasch K, Huo Yung Kai S, Moitry M, Amouyel P, Ferrières J, Dallongeville J.
Coronary heart disease incidence still decreased between 2006 and 2014 in France, except in young age groups: Results from the French MONICA registries.
Eur J Prev Cardiol. 2020; 27(11):1178-1186.

Keywords

Registry ; Risk factors ; Epidemiology ; Public Health ; Genetic factors ; Coronary heart disease ; Stroke ; Obesity ; Lung function

Team contact

Aline Meirhaeghe
Inserm researcher, group leader

aline.meirhaeghe@pasteur-lille.fr
03 20 87 72 57