Laboratory expertise
We carry out regulatory genotoxicity and (cyto)toxicity tests as part of a battery of tests adapted on a case-by-case basis, to the type of product, and according to regulatory requirements or the stage of product development.
| Regulatory tests | French documents | Documents EN |
|---|---|---|
| Gene mutation testing on bacteria (Ames test) | OECD 471 | OECD 471 |
| EAT (Enhanced Ames Test for the detection of N-Nitrosamine mutagenicity) | EMA 2024 | |
| In vitro test for chromosomal aberrations on mammalian cells | OECD 473 | OECD 473 |
| In vitro gene mutation assay on mouse L5178Y lymphoma cells (MLA/TK) or on human TK6 cells | OECD 490 | OECD 490 |
| In vitro micronucleus assay on mammalian cells | OECD 487 | OECD 487 |
| In vitro skin irritation: a test on reconstituted human epidermis | OECD 439 | OECD 439 |
| In vitro skin corrosion: a test on a human skin model | OECD 431 | OECD 431 |
| Cytotoxicity test by MTT or neutral red method (biomaterials) (according to NF EN 30993-5/ISO 10993-5) | ||
| In vivo assay of the micronucleus on bone marrow | OECD 474 | OECD 474 |
| In vivo comet testing | OECD 489 | OECD 489 |
| Acute toxicity – Method by acute toxicity class | OECD 423 | OECD 423 |
Our offers
The Genetic Toxicology Laboratory conducts regulatory tests for genotoxicity, mutagenesis and cytotoxicity, within the framework of defined test batteries case by case. The Genetic Toxicology Laboratory supports the public and private actors in their risk assessment and regulatory compliance processes.
Offers from the genetic toxicology laboratory
