Laboratory expertise
The implementation of Directive 2003/15/EC (Amendment VII to Directive 76/768/EEC) implies the prohibition of animal testing and marketing of (combinations of) cosmetic ingredients tested on animals for genotoxicity testing since 11 March 2009.
The Genetic Toxicology Laboratory of the Pasteur Institute of Lille has developed and validated cytotoxicity and genotoxicity tests on reconstructed human skin models for the study of cosmetic ingredients.
| Regulatory tests | French documents | Documents EN |
|---|---|---|
| Comet assay coupled with in vitro micronucleus testing on a reconstituted human skin model (Episkin®) | In TK6 co-culture or L5178Y | |
| In vitro micronucleus assay on reconstituted human skin basal cells (RHE®) | Curren et al., 2006 | |
| In vitro skin irritation: a test on reconstituted human epidermis | OECD 439 | OECD 439 |
| In vitro skin corrosion: a test on a human skin model | OECD 431 | OECD 431 |
Our offers
The Genetic Toxicology Laboratory conducts regulatory tests for genotoxicity, mutagenesis and cytotoxicity, within the framework of defined test batteries case by case. The Genetic Toxicology Laboratory supports the public and private actors in their risk assessment and regulatory compliance processes.
Offers from the genetic toxicology laboratory
