CRB – Biological Resource Center

The Institut Pasteur de Lille Biological Resource Centre (CRB IPL) is a technological platform of the Institut Pasteur de Lille, created in 1998, to provide technical expertise and logistics for the management of human biological resource collections within the framework of projects concerning cardiovascular, metabolic, and neurodegenerative diseases.

The CRB IPL participates in the development of basic and clinical research. An infrastructure has been put in place enabling it to create, prepare and preserve collections so that it can make biological resources available in order to best utilize the collections.

The IPL Biological Resource Center (CRB-IPL) has been certified since October 2018 according to the AFNOR NF S96-900 quality standard, "Management system of a Biological Resource Center and quality of biological resources of human origin." Since October 2024, the CRB has been certified to the NF EN ISO 20387 standard, "Biotechnology & Biobanking." The CRB-IPL is committed to a continuous quality improvement process. Its organization and areas for improvement are reviewed annually, enabling it to enhance its services.

Our services

Setting up your projects for the creation of your biological collections

• Support in developing and building your biological collection;
• Verification of regulatory and ethical documents that must be provided;
• Preparation of traceability documents, operating manuals, etc.;
• Providing logistical support for managing your biological collections.

Design of technical sampling and processing kits

• Development of technical kits specific to your request;
• Provision, during multicenter studies, of sampling and/or treatment kits.

Reception

• Implementation of a schedule for receiving and identifying biological samples and for establishing acceptance criteria for biological resources
• Receiving your biological resources (new collection or already established collection);
• Rigorous quality controls of biological resources to guarantee their compliance with the requirements defined beforehand with you in the project.

Treatment – ​​Preparation

The CRB-IPL is equipped with an NSB2, allowing it to perform the following activities :

• Centrifugation / Aliquoting of biological products: whole blood and its derivatives, buffy coat, urine, stool, fluids, hair, cerebrospinal fluid, exhaled air condensates…;
• Preparation of washed red blood cells;
• Extraction of nucleic acids and concentration;
• Subsampling for the provision of documented biological resources.

A report of all the data associated with your collection can be provided upon request.

Conservation

• Preservation of biological resources in storage enclosures at different temperatures (+20°C, +4°C, -20°C, -40°C and -80°C).

The storage units are kept in temperature-controlled and monitored rooms. Temperatures are monitored every 10 minutes. Each storage unit is equipped with a temperature probe calibrated by a COFRAC-accredited body. A mapping of the storage units is performed every three years to verify homogeneity, stability, setpoint deviation, and recovery time using nine probes.

• 24/7 monitoring by authorized personnel;
• Traceability of conservation and transfer of biological resources in case of failure;
• Possible duplication of collections, storage rooms on different buildings (common site).

Availability

• Subsampling and provision of documented biological resources;
• National and international shipments in compliance with current regulations;
• Traceability of the provision of biological resources.

All bioclinical data associated with the samples are the responsibility of the scientific manager of the collection and are therefore not controlled by the CRB.

Our catalogue of biological collections

Our catalogue is currently under construction; for any inquiries regarding our biological collections, please contact us here.

Contact us

Contact forms

• Request contact
• Request for the provision of biological samples
• Request to establish a collection
• Request to host an existing collection

Our quality approach

Download our quality approach

Download the certification