LIGAN MP – Genomics and Metabolic Diseases

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UMR 1283 / 8199

Located within EGID's facilities at the Lille University Hospital (CHU de Lille), the LIGAN-Personalized Medicine platform is dedicated to next-generation sequencing and cutting-edge genomics. The use of our high-throughput sequencers and genotyping platform is dedicated to precision medicine. It is also open to all genetic and genomic applications, regardless of the organism. It includes several Illumina sequencers (MiSeq, NextSeq, NovaSeq), multiple robots for library preparation, a dedicated genotyping platform, and other advanced genetic and genomic instruments (such as NanoString).

The platform includes several groups:

  • a group dedicated to the biobank, for receiving samples, extracting DNA and RNA, and storing samples,
  • a group dedicated to next-generation sequencing (NGS) for the development and application of protocols,
  • a group dedicated to DNA microarray genotyping for genome-wide association and methylation analysis (GWAS),
  • a group dedicated to bioinformatics,
  • a group dedicated to biostatistics,
  • a group dedicated to managing IT resources in order to handle bioinformatics/biostatistical analyses and store the generated data,
  • a group dedicated to the quality unit.

Members

Amélie BONNEFOND

DR Inserm – Director of Unit U1283

N. ORCID: 0000-0001-9976-3005
amelie.bonnefond@cnrs.fr amelie.bonnefond@inserm.fr
+03 74 00 81 00 XNUMX

Frederic ALLEGAERT

AI, Biobank

Souhila AMANZOUGARENE

IE, Bioinformatics

Anne-Sophie ANTOINE

AI, LIGAN Assistant

Alaa BADREDDINE

IE, Bioinformatics

Lionel BERBERIAN

IE, Bioinformatics

Mathilde BOISSEL

IE, Biostatistics

Raphaël BOUTRY

AI, Sequencing Technique

Mickaël CANOUIL

IE, Biostatistics

Hélène DE GRAVE

IE, HR

Aurélie DECHAUME

IE, Sequencing Technique

Fabien DELAHAYE

Postdoc, single-cell expertise

Marion DELBARRE

IE, ISO1589 Quality Unit and Sequencing Technique

Mehdi DERHOURHI

IR, Bioinformatics

Julien DEROP

IE, ISO1589 Quality Unit, Sequencing Technology, Technical Sales Manager

Emmanuelle DURAND

IE, Sequencing Technique

Philippe FROGUEL

Director U1283 Inserm

N. ORCID: 0000-0003-2972-0784
philippe.froguel@cnrs.fr

Corentin GIRARD

AI, ISO1589 Quality Unit

Mélanie HOCQUET

Secretary, HR

Nicolas KUREZOBA

Technician, Purchasing

Anne-Sophie LEDOUX

IE, Computer Science

Hélène LOISELLE

AI, Sequencing Technique

Vincent MASSY

IE, Computer Science

Lijiao NING

IE, Biostatistics

Bénédicte TOUSSAINT

IE, Sequencing Technique

Emmanuel VAILLANT

IE, Sequencing Technique

Nicolas VANEECHOUTTE

IE, Computer Science

Vincent VATIN

AI Purchase

Martine VAXILAIRE

Dr. Pasteur Lille, post-analytical co-pilot

N. ORCID: 0000-0003-0361-3630

Keywords

Team contact

Amélie BONNEFOND

DR Inserm – Director of Unit U1283

N. ORCID: 0000-0001-9976-3005
amelie.bonnefond@cnrs.fr amelie.bonnefond@inserm.fr
+03 74 00 81 00 XNUMX

Publications

Nat Metab. 2020 Oct;2(10):1126-1134.

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes.

Bonnefond A, Boissel M, Bolze A, Durand E, Toussaint B, Vaillant E, Gaget S, Graeve F, Dechaume A, Allegaert F, Guilcher DL, Yengo L, Dhennin V, Borys JM, Lu JT, Cirulli ET, Elhanan G, Roussel R, Balkau B, Marre M, Franc S, Charpentier G, Vaxillaire M, Canouil M, Washington NL, Grzymski JJ, Froguel P.

Nat Med. 2019 Nov;25(11):1733-1738.

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.

Baron M, Maillet J, Huyvaert M, Dechaume A, Boutry R, ​​Loiselle H, Durand E, Toussaint B, Vaillant E, Philippe J, Thomas J, Ghulam A, Franc S, Charpentier G, Borys JM, Lévy-Marchal C, Tauber M, Scharfmann R, Weill J, Aubert C, Kerr-Conte J, Pattou F, Roussel R, Balkau B, Marre M, Boissel M, Derhourhi M, Gaget S, Canouil M, Froguel P, Bonnefond A.

Nat Genet. 2018 Feb;50(2):175-179.

Loss-of-function mutations in ADCY3 cause monogenic severe obesity.

Saeed S, Bonnefond A, Tamanini F, Mirza MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E, Vaillant E, Haseeb A, De Graeve F, Rabearivelo I, Sand O, Queniat G, Boutry R, ​​Schott DA, Ayesha H, Ali M, Khan WI, Butt TA, Rinne T, Stumpel C, Abderrahmani A, Lang J, Arslan M, Froguel P.

Eur Respir J. 2017 May 11;49(5):160231

Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis.

Judge PA, Borie R, Kannengiesser C, Gazal S, Revy P, Wemeau-Stervinou L, Debray MP, Ottaviani S, Marchand-Adam S, Nathan N, Thabut G, Richez C, Nunes H, Callebaut I, Justet A, Leulliot N, Bonnefond A, Salgado D, Richette P, Desvignes JP, Lioté H, Froguel P, Allanore Y, Sand O, Dromer C, Flipo RM, Clément A, Béroud C, Sibilia J, Coustet B, Cottin V, Boissier MC, Wallaert B, Schaeverbeke T, Dastot le Moal F, Frazier A, Ménard C, Soubrier M, Saidenberg N, Valeyre D, Amselem S; FREX consortium, Boileau C, Crestani B, Dieudé P.

Nat Genet. 2012 Mar 11;44(4):456-60, S1-3.

Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis.

Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P, Bagnis CI, Koenig J, Konrad M, Landais P, Mourani C, Niaudet P, Probst V, Thauvin C, Unwin RJ, Soroka SD, Ehret G, Ossowski S, Caulfield M; International Consortium for Blood Pressure (ICBP), Bruneval P, Estivill X, Froguel P, Hadchouel J, Schott JJ, Jeunemaitre X.

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