The laboratory is a Joint Research Unit (UMR) under the supervision of INSERM, the University of Lille, the University Hospital of Lille and the Pasteur Institute of Lille.

UMR 1011 studies the biological mechanisms controlling the development and progression of 2 type diabetes, liver disease associated with a metabolic dysfunction (MASLD) and their cardiovascular complications, with the aim of developing preventive and therapeutic strategies.

To this end, the laboratory studies the regulation of genes involved in these pathologies, with a particular focus on nuclear receptors (NRs), which constitute potential therapeutic targets. Recently, the laboratory has contributed to:

• To demonstrate the role of RNs in metabolic disturbances during type II diabetes, of the MASLD and their complications
• Characterize the role of RNs in inflammatory processes of adipose tissue and vascular wall

However, the full roles of RNs in the developmental processes of type II diabetes, MASLD and associated complications are still not elucidated.

Thus, to answer these different questions, UMR1011 is divided into 6 research themes.