Researchers and engineers from UMR 9031 use biophysical techniques to characterize structure and protein-protein interactions at the molecular level, such as X-ray crystallography, NMR spectroscopy ou cryogenic single-particle electron microscopyThey have extensive experience in preparing recombinant proteins on the scale required for their studies. They also use artificial intelligence tools in structural biology. Protein interactions are then characterized by complementary approaches including cell biology.

Unit presentation

The Unit's objectives are to deciphering the molecular mechanisms underlying physiology and pathology, as well as researching and to characterize new compounds presenting therapeutic potential. To achieve these objectives, we use an integrated approach to structural biology, employing several techniques that allow us to characterize the structure, interactions et protein dynamicsThe team possesses particular expertise in the study of proteins inherently disordered, from their post-translational modifications and from the formation of transient complexes.