age-related diseases are complex and multifactorial diseases resulting from the interaction of genetic factors, biological and environmental, the consequences of which on quality of life and life expectancy must be characterized in order to develop preventative tools et effective treatmentsUntil recently, these various age-related pathologies were primarily considered as concurrent pathologies and were therefore studied, evaluated, and ultimately treated relatively independently. However, it is becoming increasingly clear that these diseases are interconnected. They may share common pathophysiological mechanisms and/or some may predispose individuals to the development of other diseases. This evolution in our understanding of age-related diseases therefore implies a strong interdependence which may concern the same organ ou involve communication between the organsUnderstanding age-related diseases means studying them individually, but also integrating several levels of interaction, at epidemiological level, biological and/or molecular.

To address these complexities and interconnections, our project relies on an interdisciplinary unit that combines basic research, translational and epidemiologicalOur main objective is to improve our understanding the impact on life expectancy of the main age-related diseases by characterizing the determinants that can be exploited to treat and prevent interactions and consequences of these chronic diseases.