INSERM U1167 – University of Lille – Lille University Hospital – Pasteur Institute of Lille
Presentation
Our project aims to deciphering the genetic landscape of MA and related disorders in order to better understand the pathophysiological processes involved in the development of these pathologies.
Our team project revolves around of two main axes : (i) the characterization of the still missing genetic component of AD and related disorders, in particular by characterizing associations of rare variants; and (ii) the development of post-genomic approaches in order to give a biological and pathophysiological significance to the generated genetic data. In particular, we postulate that many priority risk genes for AD (already known or yet to be characterized) are involved in synaptic functions/dysfunctions.
