Molecular and cellular pathophysiology of cardiometabolic diseases

Presentation

Our project aims to decipher how non-genetic risk factors integrate environmental signals, translate them into an adaptive cellular response and contribute to maintaining metabolic homeostasis. Based on our expertise and data collected over the past few years, we hypothesize that these environmental factors shape epigenetic, epitranscriptomic, and post-translational modifications which influence gene transcription, protein translation and function contributing to cellular plasticity et to dysfunctions in the interaction between organs, ultimately leading to the development of cardiometabolic diseases such as heart failure, obesity and the 2 type diabetes.