Le intestinal microbiota plays a major role in metabolic and cardiovascular diseases. The team from Dr. Marc-Emmanuel Dumas (METAB-OMICS unit CNRS UMR 8199, INSERM U1283, Univ/CHR Lille & Imperial College London) seeks to identify early markers of these pathologies, particularly by analyzing the metabolic activity of the gut microbiotaBased on three independent studies, including a large cohort of patients followed over time, the researchers studied the dialogue between the microbiota, the kidney and the heart. Researchers have identified microbial metabolites involved in the transition between good metabolic health and the onset of cardiovascular diseases, including the "whispering" awakens inflammation and the progression towards the disease. This work suggests promising perspectives for early detection of metabolic and cardiovascular diseases, as well as for patient care.
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
Kanta Chechi, Rima Chakaroun, Antonis Myridakis,…Dusko Ehrlich, Karine Clément & Marc-Emmanuel Dumas
Nature Communications.2026 Mar 5. https://www.nature.com/articles/s41467-026-69405-0
U1283 – UMR8199 “METAB-OMICS Multi-omics and the pathophysiology of metabolic diseases"
University of Lille – Lille University Hospital – CNRS – Inserm – Pasteur Institute of Lille
