La non-alcoholic fatty liver disease is an excess of fat in the liver, unrelated to alcohol consumption, but often associated with obesity. One of the current difficulties is predicting the progression of the disease. The team at Professor François Pattou (University of Lille, Lille University Hospital, Inserm U1190, EGID, Pasteur Institute of Lille), a world-renowned research group in the field, has made a major breakthrough. Researchers analyzed and followed over 1000 patients with this condition for several years. By combining complex genetic, transcriptomic, metabolic, histological, and clinical data, they identified two groups of patients whose clinical course differs, particularly in terms of the risk of cardiovascular complications. This work was published in the prestigious journal Nature Medicine could allow for personalized treatment to be offered to patients in order to better control the progression of the disease.
Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease
Violeta Raverdy and al. Nature Medicine.
U1190 “Translational research on diabetes (TRD)
Lille University Hospital – INSERM U1190 – University of Lille – Pasteur Institute of Lille – EGID
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